Author's response to reviews Title: Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs Authors:
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Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adverse events (AEs). The proton pump inhibitor esomeprazole has been found to be effective for gastroprotection in NSAID users, but few long-term studies have been conducted in Japa...
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Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of serious gastroduodenal events. To minimise these risks, patients often require concomitant acid-suppressive therapy. We conducted a literature review of clinical trials examining use of ranitidine 150 mg twice daily to heal gastroduodenal ulcers (GU) in NSAID recipients. Seven studies were identified. After 8 ...
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10.1586/14750708.3.2.227 © 2 Ulcer and ulcer symptoms related to the use of non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin constitute a major global health issue. Despite various attempts to prevent and heal injuries inflicted by NSAIDs and aspirin, acid suppression remains one of the cornerstones in the management of NSAID-associated ulcers. Esomeprazole, the S-optical isomer (enan...
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